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STAT3 activation in HER2-overexpressing breast cancer promotes epithelial-mesenchymal transition and cancer stem cell traits

Traditionally, it was narrowly conceptualized as the cross-resistance of tumor cells to other drugs with divergent structures and mechanisms following exposure to a single anti-tumor agent, with its theoretical underpinning primarily focused on the efflux pump effect centered on the overexpression of the ABC transporter family [11]

A handful passed

For each z-slice, a relative signal was obtained by calculating the ratio intensity (mean gray value) for Ubx signal (488 nm) relative to the DAPI signal in T2-T3 segments (which only expressed ectopic Ubx protein) using the same region of interest (ROI)

Changes in antioxidant status, protein concentration, acetylcholinesterase,(Na+, K+)-, and Mg 2+-ATPase activities in the brain of hyper-and hypothyroid adult rats