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In preclinical and mechanistic literature, this signaling axis has been studied for its role in: neuronal structure dendritic branching synaptic organization cellular communication and structural plasticity Because of this pathway association, Dihexa has drawn attention in laboratory settings where researchers are evaluating signal transduction, synaptic density, neurite outgrowth, and network-level structural organization in non-human test systems

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Importantly, not only the core subunits but also two low-molecular-weight guanine nucleotide-binding proteins, Rac1 and Rap, are required for activation

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MRS, magnetic resonance spectroscopy