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It cites a 2015 meta-analysis of 14 randomised controlled trials finding consistent but modest HbA1c reductions, while noting many trials lacked rigorous controls and that publication bias toward positive findings is likely

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Lyophilisation removes bulk water while preserving the lipidated peptide in a low-moisture, non-reactive matrix, which is critical for compounds bearing long-chain fatty-acid conjugates that are susceptible to hydrolysis in aqueous solution

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