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[91] Macrophages during SLE fail to mature their lysosomes and as a result have impaired degradation of internalized apoptotic debris, which results in chronic activation of Toll-like receptors and permeabilization of the phagolysosomal membrane, allowing activation of cytosolic sensors

GLP-1R agonists are known to significantly decrease the cardiovascular risk of diabetic patients, while they are currently being investigated to determine their potential efficacy for neurodegenerative diseases associated to cardiometabolic pathology

Hanahan D, Weinberg R (2011) Hsration

Li H, Liu C, Li R, Zhou L, Ran Y, Yang Q, et al