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Furthermore, cytokines such as TNF- and interferon-gamma have been shown to induce extrinsic apoptosis in melanocytes in addition to ROS

This may lead to poor nutrition, which is particularly concerning for seniors who already face dietary challenges

(January 2023)

Although regulating the MUFA/PUFA ratio by lactate through the SCD1/ASCL4 pathway does affect membrane lipid peroxidation sensitivity, this protective effect against ferroptosis may be more highly dependent on the state of the intracellular antioxidant system (83)