The earlier marketed amylin-class agent, pramlintide, is a triple-proline-substituted analog engineered specifically to reduce fibrillation, but it retains a short duration of action
Inhibiting NADPH oxidases to target vascular and other pathologies: an update on recent experimental and clinical studies
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Analysis of lipid droplets from Chinese hamster ovary (CHO) cells by mass spectrometry has identified, in addition to perilipin, more than 40 structural and signaling proteins, as well as enzymes involved in lipid synthesis, storage, and utilization, suggesting that the lipid droplet should be considered a metabolic organelle rather than an inert storage site (70)