Weight loss with GLP-1 therapy alone averages 1015% of baseline body weight over 68 weeks in clinical trials, with some patients achieving 20% or greater reductions
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This initiates these cells to produce cytokines such as IL-4, IL-5, IL-9, and IL-13, that can activate structural cells in the lungs, namely goblet cells and smooth muscle cells, initiating airway remodeling resulting in hyperresponsive airways [4]
Landeta et al., 2011)