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Moreover, the redox reaction nanoassembly R-mPDV/PDV/DOX/sil formed by self-assembly of three glutathione responsive polymers can be broken down by GSH-induced cleavage of 3, 3-dithiodipropionic acid (DA) to achieve abrupt drug release and efficient lactate dehydrogenase A (LDHA) silencing thereby inhibiting G-CSF and GM-CSF production and further inhibiting MDSCs recruitment and enhancing anti-tumor immunity (128)

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