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Adiels M, Taskinen MR, Packard C, Caslake MJ, Soro-Paavonen A, Westerbacka J, Vehkavaara S, Hakkinen A, Olofsson SO, Yki-Jarvinen H, Boren J (2006) Overproduction of large VLDL particles is driven by increased liver fat content in man

This seemingly small chemical modification drastically alters its pharmacokinetics, making the molecule highly lipophilic (fat-soluble)

Long-term arterial remodeling begins as reduced inflammation allows blood vessels to regain elasticity

Lancet Diabetes Endocrinol 7:776785 de Leeuw AE, de Boer RA (2016) Sodium-glucose cotransporter 2 inhibition: cardioprotection by treating diabetes a translational viewpoint explaining its potential salutary effects

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