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Reduced IDO1 is associated with the progression of colonic inflammation in mice, and supplementation with tryptophan (Trp) or an AhR agonist can ameliorate intestinal inflammation, suggesting that this pathway may have important clinical value in the treatment of IBD (94, 95)

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Additional well-designed, prospective studies are needed to confirm the potential benefit of GLP-1 receptor agonist treatment for patients with advanced CKD or ESKD." For further information: DOI: 10.1001/jamanetworkopen.2022.1169 Keywords: CKD, ESKD, GLP-1 receptor agonist, DPP-4 inhibitors, type 2 diabetes, JAMA Network Open, chronic kidney disease, end-stage kidney disease, National Health Insurance Research Database of Taiwan, MACCE, Mortality rate

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