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When the mitochondrial membrane potential is changed due to damage, PINK1 blocked from entering mitochondria accumulates on the OMM and is activated by self-phosphorylation, indirectly activating DRP1 to facilitate mitochondrial fission [66,67,68]

Lysine-specific demethylase 1 aggravated oxidative stress and ferroptosis induced by renal ischemia and reperfusion injury through activation of TLR4/NOX4 pathway in mice

GLP-1 receptor agonists (semaglutide, tirzepatide) are peptide drugs cleared by proteolytic cleavage, not by hepatic CYP450 enzymes, so there is no enzymatic pathway linking the two

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