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Nature 254, 667671

Heightened Fatigue: Some individuals experience GLP-1 fatigue as the medication reaches its peak

Along this line, a recent large case-control study from 2024 including 162,253 obese patients treated with GLP-1 RAs and a matched group of untreated patients found an association between GLP-1 RAs and increased risk of depression, anxiety and suicidal behavior [10]

Semaglutide GLP-1 has been shown to aid in weight loss by reducing appetite and increasing feelings of fullness, leading to decreased food intake

The diagnosis is primarily clinical, although questionnaires can help evaluate pain location and severity