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These adverse reactions were not present at baseline, occurred more commonly on dapagliflozin and metformin HCl than on placebo, and occurred in at least 2% of patients treated with either dapagliflozin 5 mg or dapagliflozin 10 mg

Incorporation of Biotin into Biotin-Requiring Enzymes Incorporation of biotin into the biotin-requiring enzymes involves the activity of holocarboxylase synthetase (also known as protein-biotin ligase) that is encoded by the HLCS gene

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