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J Virol 78(23):1306213071 Lsing M, Goldbeck I, Manno B, Oellerich T, Schnyder T, Bohnenberger H, Stork B, Urlaub H, Batista FD, Wienands J et al (2013) The Dok-3/Grb2 protein signal module attenuates lyn kinase-dependent activation of syk kinase in B cell antigen receptor microclusters

the following properties are derived from preclinical data

After roughly 20 minutes five half-lives approximately 97% of an injected dose is gone from plasma

In mouse models of HIV infection, increased FcR binding enhances virus control but only over certain ranges of nAb titre 172

Inhibition of DYRK1A stimulates human beta-cell proliferation