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Although a small observational pilot study on 15 diabetic patients with biopsy-proven NAFLD demonstrated biochemical and histological improvement after a 1-year course of sitagliptin [89] further RCTs failed to demonstrate any beneficial effect of sitagliptin on NAFLD in diabetic patients

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Most studies have been conducted in animal models or small human trials with high risk of bias, and findings often lack replication in larger, well-controlled clinical studies

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