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In the first shuttle, cytosolic NADH is oxidized to NAD + by MDH1 in conjunction with the reduction of oxaloacetate (OAA) to malate

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Glutathione's unique role lies in its ability to recycle and regenerate other antioxidants like vitamin C and vitamin E, making it essential for the body's defence against harmful molecules

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10.1371/journal.pone.0146797 Summary Keywords autism, folinic Acid, glutathione, methylation, methylcobalamin, oxidative stress, tetrahydrobiopterin Citation Delhey LM, Tippett M, Rose S, Bennuri SC, Slattery JC, Melnyk S, James SJ and Frye RE (2018) Comparison of Treatment for Metabolic Disorders Associated with Autism:Reanalysis of Three Clinical Trials