Albiglutide Harmony outcomes was a double-blind trial that included a total of 9,463 T2D participants of 40 years of age and a history of CVD, who were allocated to an albiglutide (3050 mg weekly) group or placebo group ( Renoprotection of GLP-1RAs is Largely Dependent on Reduction of Albuminuria As described above, GLP-1RAs have no clinically important effect on eGFR and hard renal endpoints
This review article discusses the potential antidepressant effects of GLP-1RAs, especially in the context of their action on the processes related to neuroprotection, inflammation, stress response, energy metabolism, gut-brain crosstalk and the stability of the gut microbiota
Clinical studies in humans have not been published so far (41, 51)
The FDA-approved prescribing information recommends gradual dose titration over several weeks to minimize these symptoms
Overall, the titration schedules that come with FDA-approved GLP-1 medications were developed through extensive research involving thousands of participants, and they exist for both safety and efficacy reasons
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