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Copper is an essential trace element required for numerous enzymatic and structural proteins involved in redox balance, extracellular matrix organisation, and cellular metabolism

A scoring system for the classification of beta-thalassemia/Hb E disease severity

Specifically, increased expression of peroxisome proliferator-activated receptor- coactivator-1 protein, a key regulator of mitochondrial biosynthesis, disrupts the mitochondrial structure and leads to dysfunctional proliferation, which is involved in the development of certain cardiac diseases, such as heart failure and atherosclerosis (45)

These molecular defects converge on distinct stress programs in individual organelles, impairing proteostasis, vesicular trafficking, metabolic function or degradative capacity

Randomized controlled trials have confirmed the homocysteine-raising effect of coffee intakes of about four cups/day