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Many patients see their pace of progress change once they reach the full therapeutic dose, though the timing and amount varies by individual

Endocrinology 151 , 17431750 (2010)

Nicotinamide and allopurinol seem to be effective in reducing the inflammation of soft tissue but the data sustaining this conclusion were obtained in a rather small sample of GO patients affected with both moderate-to-severe and mild GO ( in vitro results on the use of pentoxifylline are promising, but clinical studies provided conflicting results ( in vitro findings reported above, one can speculate that quercetin and -carotene might be the most promising, but clinical trials are needed to confirm this hypothesis

Sen 2008

While thorough questionnaires can identify most contraindications and risk factors, the lack of physical examination may miss subtle signs of underlying conditions that could affect treatment safety or efficacy