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To achieve this, these enzymes can bind non-substrate ligands (ligandin function) and/or catalyze the conjugation of glutathione onto the targeted molecules, the latter activity being exhibited by GSTs having a serine or a tyrosine as catalytic residues

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Isorce N, Testoni B, Locatelli M, Fresquet J, Rivoire M, Luangsay S, et al

Indirect inhibition of GPX4 using l-buthionine sulphoximine (L-BSO

Hyperexcitability of motor nerve terminals can be incited by disrupted energy metabolism, ischemic damage resulting from reduced intravascular volume, and electrolyte imbalances