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Moreover, a decrease in atherosclerotic cardiovascular disease (ASCVD) has been found in people treated with semaglutide who were obese or overweight, but, this trend was not statistically significant [28]

The integration of glucagon-mediated energy expenditure with the appetite-suppressive and insulinotropic effects of GIP and GLP-1 agonism is hypothesized to explain the substantial weight loss and metabolic improvements observed in Phase 2 trials

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Identifying Contraindications Some lab results might wave a red flag, making GLP-1 treatment not the best option or requiring extra care

Summary: Feeling cold has been reported by some people taking GLP-1 weight loss injections, but it is not listed as a recognised side effect in prescribing information