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In these situations, vitamin B12 is the priority treatment, as untreated deficiency can lead to irreversible neurological complications

These compounds typically regulate several biological pathways, including the monoamine neurotransmitter system and the hypothalamicpituitaryadrenal (HPA) axis, thereby effectively alleviating depressive symptoms [6, 7]

Moreover, the administration of shiitake extract to rats was shown to decrease blood ethanol or acetaldehyde concentrations owing to a rise in the enzymatic activities of cytosolic ADH, cytosolic ALDH, and mitochondrial ALDH (ALDH2) in the stomach and liver (UtoKondo et al., 2020)

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