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Ann Allergy, Asthma, Immunol 103:8283 Ranke MB, Wilton P (1994) Adverse events during treatment with recombinant insulin-like growth factor I in patients with growth hormone insensitivity

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Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130

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