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The first is a glutamine-cleaving enzyme featuring an internal peptide inhibitor that is removed when exposed to acidic pH, triggering the enzymatic reaction

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GLP-1R can also signal through G q , which may enable this receptor to function under conditions of hyperglycemia (Oduori et al., 2020), a hypothesis challenged by the observation that GIPR has also been shown to signal through G q (Shaaban et al., 2016