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Single-dose pen and single-dose vial Store in a refrigerator at 2C to 8C (36F to 46F) If needed, each single-dose pen or single-dose vial can be stored at room temperature up to 30C (86F) for up to 21 days If stored at room temperature, do not return to the refrigerator Discard if not used within 21 days after removing from the refrigerator Multi-dose vial or single-patient-use KwikPen Unopened Store in a refrigerator at 2C to 8C (36F to 46F)

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The review confirmed that NNMT-mediated NAD+ depletion impairs mitochondrial function, SIRT activity (particularly SIRT1 and SIRT3), redox balance, and energy metabolism, creating conditions relevant to cardiovascular disease research models