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The condition is defined as the presence of fat in more than 5% of liver cells (hepatocytes) on histology, or more than 5% liver fat content on MRI

However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)

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