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Tirzepatide, better known as Zepbound for weight loss and Mounjaro for treatment of type 2 diabetes, helped patients lose more than 20% of their starting body weight across the reviewed studies

Some studies suggest that individuals with obesity may have alterations in GLP-1 signaling, though findings are heterogeneous

doi: 10.3390/nu11061245 132 PolKChristensenRBartelsEMRabenATetensIKristensenM

People starting from lower muscle mass, those eating very little protein, and anyone doing zero resistance training are also at elevated risk of an unfavorable ratio

Retatrutide is a ~39-amino-acid synthetic peptide with fatty acid modifications