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KEY FINDINGS Average weight loss on treatment: 7.9 kg (all GLP-1s) 16.1 kg (newer GLP-1s like semaglutide/tirzepatide) Weight regained after stopping: 0.70.8 kg/month 8.39.6 kg regained in the first year Full return to baseline: 0.9 years (older GLP-1s) 1.7 years (newer GLP-1s) Bottom line: GLP-1s are effective, but without ongoing treatment or structured long-term care, the benefits fade quickly

doi: 10.1001/jama.2017.14752 2 GunturuSDhanasekaranSBhattMShahAPatelRSBhattSet al

Fact: In many cases, doctors simply suggest a slower dose titration or better hydration strategies

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