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This represents a pharmaceutical design strategy of creating selectivity through structural modification, providing therapeutic benefits while minimizing unwanted effects

The mechanistic resolution at the level of specific protein-protein interactions and signaling pathway activation has been less complete than for some other research peptides with single-receptor mechanisms

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For chromatin immunoprecipitation assays, PC-3 cells were cultured and transfected with FBI-1 and siFBI-1 (siFBI1-1 and siFBI1-2), respectively, after which cell samples were collected and fixed and cross-linked with 4% paraformaldehyde and the cells were broken [49,50]