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Die SURMOUNT-1-Studie [8] umfasste 2539 bergewichtige Probanden, die ber 72 Wochen 5, 10 oder 15 mg Tirzepatid im Vergleich zu Placebo erhielten

Standard doses are intended to maximize blood sugar control and weight loss

The trial results released by Lilly havent been published in a medical journal or reviewed by independent experts to ensure the accuracy of the findings

In addition to SGLT2 inhibitors and GLP-1 receptor agonists, finerenone, a nonsteroidal mineralocorticoid receptor antagonist, has demonstrated significant cardiovascular and kidney-protective effects in people with type 2 diabetes mellitus and CKD or HF [129-132]

GLP-1 receptor activation slows gastric emptying and increases satiety