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Renal function is the other variable most protocols ignore until it's too late

Lu GD, Shen HM, Chung MC, Ong CN

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significantly downregulated the levels of Fabp4 in adipose tissue and Srebp1c , Nr1h3 in the liver, promoting triglyceride hydrolysis and fatty acid oxidation in adipose tissue and liver of obese mice, inhibiting the fatty acid synthesis pathway to improve lipid metabolism

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