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Supplementary material The Supplementary Material for this article can be found online at: References 1 AsadiA.Shadab MehrN.MohamadiM

pmid:16429122 20

This inflammatory state is coupled with NLRP3caspase-1 activation, oxidative/nitrosative stress and imbalances in lipid-derived (eicosanoids, bile acids, SCFAs) and amino acid-derived (glutamateGABA, tryptophanserotonin, NO) signalling pathways, all of which lower nociceptive thresholds