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The ability of the lung to utilize GSH from the plasma seems evident based on the fact that during the rest period the plasma GSH spikes at 4 hours while at the same time point the lung GSH is slightly higher and the ELF GSH is still rising

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In addition, GLP-1 expression was down-regulated in wild-type Lox5 cells knocked out by FNDC5, and the induced expressions of lipolysis and autophagy-related genes and proteins were also inhibited, such as ATGL, HSL, and hepatic lipase deficiency gene (LIPC), suggesting that GLP-1 expression is also regulated by FNDC5, and may also provide therapeutic targets for lipid metabolism-related diseases

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