Whether the promising preclinical pharmacology will result in successful clinical trials is a question that will be answered in coming years
Mouse model of B12 deficiency Female C57BL/6 and SCID mice were fed with a diet similar to control group normal diet (Teklad 2014S, ENVIGO), but with no added B12 and with 5% Pectin (Tekland custom diet TD.170206, ENVIGO)
Abbreviations ABTS: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) AQbD: Analytical quality by design BBD: Box Behnken design BSA: Bovin serum albumin COX-2: Cyclooxygenase-2 DPPH: 2,2-diphenyl-1-picrylhydrazyl FTIR: Fourier Transform Infrared spectroscopy FESEM: Field Emission Scanning Electron Microscope HPTLC: High High-performance thin layer chromatography HRBC: Human red blood cell NCDs: Non-communicable diseases NSAID: Non-steroidal anti-inflammatory drug ROS: Reactive oxygen species RSD: Relative standard deviation SPF: Sun protection factor TNF-: Tumor Necrosis Factor alpha References Nediani C, Dinu M
Previous animal studies have shown that the intraperitoneal administration of various TRPV1 antagonists results in hyperthermia 42
Contraindications: Do NOT take during pregnancy, as it can increase uterine contractions (though it has been used to induce labor) or while breastfeeding.
