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The reduced GSAAT(C168S), GSAAT(C190S) and GSAAT(C396S) mutants, as well as the double mutant GSAAT(C168S/C190S), each exhibited only half as much activity as that measured in the presence of DTT or TRX-f1 ( Figures 6B, C )

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Switching from semaglutide to retatrutide may be appropriate in some situations, but it should only be done under medical supervision