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7 While side effects show how GLP-1s can influence the brain both directly and indirectly in a negative sense, the question remains: Can GLP-1s positively impact cognition and brain health

They are not as effective as the injected versions of the drugs.

9 Research gaps and future priorities 9.1 Reproductive-oriented RCTs: shifting from metabolic surrogates to hard endpoints To date, most GLP-1RA trials in PCOS have been designed around metabolic efficacy (weight change and insulin-resistance/glycaemic indices) as the primary outcomes, with reproductive outcomesovulation, clinical pregnancy, and live birthreported inconsistently and often as secondary or exploratory measures

Temporary fatigue post-treatment is common with intravenous therapy

Melanotan I binds to the melanocortin 1 receptor (MC1R) and its stimulation causes an activation of the melanocytes