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When medications are exposed to temperature excursions, their safety and efficacy cannot be assured

Do not use these medications if you have fever, bloody stools, or severe abdominal pain, and contact your doctor if symptoms persist beyond 48 hours

His1 of exendin-4 formed only limited transient interactions with TM5, however more persistent interactions with E364 6.53 in TM6 were evident in the MD simulations (Supplementary Table 3)