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These adverse reaction reports are self-reported by patients and their health-care providers, so they don't undergo review

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By contrast, gastrointestinal events such as nausea and vomiting are generally recorded more systematically and are commonly treated as key tolerability endpoints (68)

Hormones related to obesity, satiety, weight control, and energy expenditure (such as leptin, adiponectin, ghrelin, and orexin) were found to be altered in individuals with OSA, while the role of gut microbiota to the pathogenesis of both obesity and OSA is under intense investigation [3, 15, 21, 22]