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Notably, a significant increase in the rate of thiazine formation has been observed at basic pH values, indicating a base-dependent mechanism that involves nucleophilic attack of the succinimide by the N-terminal amine

Transition period Allow 7 days between your last Wegovy dose and first Mounjaro injection Start at a lower Mounjaro dose (typically 2.5mg or 5mg) Monitor your response closely for 4-8 weeks 3

Treatments were blinded by masking sample labels

Three important protocols include: Cycling using steroids for a defined period (e.g., 812 weeks) followed by time off to allow hormonal recovery

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