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The term ferritinophagy is used to describe the degradation of transferrin and ferritin by the autophagy machinery, which releases Fe (II) into the labile iron pool and triggers labile iron overload, lipid peroxidation, membrane damage, and ferroptosis ( Major Pathways in Ferroptosis Regulation As mentioned above, ferroptosis is a type of cell death that depends on iron-mediated oxidative stress and lipid peroxidation-mediated cytotoxicity, and its main characteristics are iron accumulation and lipid peroxidation

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The type 1 IGF receptor (IGF-1R) IGF-1R is a transmembrane receptor tyrosine kinase structurally related to the insulin receptor

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