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Given the reduced glutamine levels observed in the MMA group, lower NAAD may reflect impaired glutamine-dependent NAD + synthesis rather than a primary defect in NAD metabolism

This section discusses the role of neuroinflammation in PEM from three perspectives: the formation of central inflammation, neuronal dysfunction, and positive feedback mechanisms

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Upon neutron irradiation, the COF not only released high-energy He and Li particles ( Figure 14C ) but also gradually released loaded imiquimod due to structural defects in the COF capsule ( Figure 14D ), promoting macrophage polarization and enhancing immune responses