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We were concerned that in our previous study, we only observed the transient increase in I sc in ~50% of preparations after AngII application, and therefore aimed to minimise this variability by removing the entire submucosal layer as well as the tunica muscularis mucosae from our colonic preparations (Fig

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However, if dizziness prevents you from working, driving safely, or performing daily activities, discuss dose adjustment or escalation timing with your providerslowing the progression to higher doses may allow your body to adapt more comfortably