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Additionally, geniposide increases glucose-stimulated insulin secretion by increasing the level of glucose transporter protein 2 (GLUT2), which activates glucagon-like peptide-1 (GLP-1) in pancreatic -cells via a phosphatidylinositol 3-kinase (PI3K)-dependent mechanism ( Geniposide also modulates insulin signaling-related molecules, enhances glucose uptake by increasing insulin receptor substrate-1 (IRS-1) and GLUT1 protein levels, and blocks the IR-induced phosphorylation of IRS-1 and AKT Thr308

Results Cisp administration (8 mg/kg, IP) significantly impaired liver function, increased oxidative stress, promoted apoptosis (increased BAX, CASPASE-3, and decreased BCL2) and disrupted homeostasis by increasing the ferroptosis upstream ferritinophagy (decreased ferritin and increased NCOA4)

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Overall, the authors calculated that approximately 93 million patients would be eligible for treatment with semaglutide

However, this effect occurs through gastric distension and increased fullness rather than changes in GLP-1 or other hormones