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Who Should Take Semaglutide for Weight Loss The FDA approved semaglutide specifically for chronic weight management in certain patients: BMI 30 kg/m^2 (obesity) BMI 27 kg/m^2 plus at least one weight-related health issue like type 2 diabetes or hypertension Those with a history of certain medical conditions should not take semaglutide: Multiple endocrine neoplasia syndrome type 2 (MEN 2) Medullary thyroid carcinoma Severe gastrointestinal disease Always consult a healthcare professional before starting semaglutide