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Contraindications:: Patients with a personal or family history of medullary thyroid carcinoma (based upon animal data - see FDA Warning) History of hypersensitivity to semaglutide or any of its excipients (serious reactions including angioedema & anaphylaxis have been reported) Side Effects: GI Adverse events: nausea, vomiting, constipation, diarrhea (~5-15%) most GI side side effects occur during dose initiation or escalation and wane after a few weeks (Drucker, 2024)

Semaglutide is a transformative obesity medication with Phase 3 data from tens of thousands of participants, FDA approval, proven cardiovascular benefit, and years of real-world use at scale

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It has a clean, modern profile for advanced metabolism-focused investigation

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