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Dopamine D1/5 receptor-mediated long-term potentiation of intrinsic excitability in rat prefrontal cortical neurons: Ca 2+ -dependent intracellular signaling

In one study, the apparent surgical cure rate for prolactinomas, although good in the short term, decreased on re-evaluation during long-term follow-up.12 Hyperprolactinemia recurred within 5 years after surgery in about 50% of patients with microprolactinomas who were initially thought to be cured.12 In other series, the rate of recurrence of hyperprolactinemia following initial cure by surgery ranged from 20% to 40%.13 However, recurrence of hyperprolactinemia after surgery is not necessarily a permanent feature and does not inevitably indicate operative failure.13 , 14 Re-evaluation of long-term results indicates a success rate of about 75% for surgical removal of microprolactinoma

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