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Additionally, another study demonstrated that AS-IV upregulates p-Akt/Akt and Bcl-2 expression in a concentration-dependent manner while downregulating pro-apoptotic proteins such as Bax and caspase-3, thereby mitigating I/R-induced apoptosis ( I/R injury induces intense local and systemic inflammatory responses, which exacerbate tissue damage and impede left ventricular recovery (Lu M

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Of 305 metabolites analyzed by LC-MS, 53 showed significantly different abundance between DMF and PBS treatments (Fig