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Matikainen N, Mnttri S, Schweizer A, et al

10.1038/s41401-019-0275-z 40 ZhangX.MaY.LvG.WangH

OLETF rats, Otsuka LongEvans Tokushima Fatty rats

Berberine is a quaternary ammonium compound, meaning it carries a permanent positive charge

ROS and RNS production are facilitated by pattern recognition receptors [C-reactive protein (CRP), toll-like receptors] capable of recognizing pathogen (bacterial/viral)-associated molecular patterns and/or damage-associated molecular patterns in apoptotic or damaged cells (92100) (Figure 6)