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Whilst GLP-1 receptor agonists like semaglutide typically have neutral or beneficial cardiovascular effects in clinical trials, the combination with a stimulant medication could theoretically alter this profile

In between-drug comparisons, all tirzepatide doses were comparable with semaglutide 2.0 mg and superior to semaglutide 1.0 mg and 0.5 mg

Semaglutide belongs to the class of GLP-1 receptor agonists (glucagon-like peptide-1 receptor agonists) that help improve blood sugar control by enhancing insulin secretion and reducing glucagon release in a glucose-dependent manner

For the readers convenience, we will interchangeably use the terms G(C)LP and GLP