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The aging of the population, cardiorenal metabolic syndrome, and the global obesity epidemic are the main factors that contribute to heart failure due to associated reductions in cardiac insulin metabolic signaling and insulin resistance [136,137,138]

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The sequences of the primers used in this study are provided in Supplemental Table 2

The rats receiving GABA therapy (PPA-GABA group) exhibited degenerative changes and reduced neuron density in the CA4 region, similar to PPA-treated group (Figure 3E)

The effect of smoking cessation on body weight and other metabolic parameters with focus on people with type 2 diabetes mellitus